Associations Between Deep Learning-Derived Infrapatellar Fat Pad Volume on MRI with Cartilage Thickness and Imaging Features of Knee Osteoarthritis: Data from the Osteoarthritis Initiative

To investigate associations between infrapatellar fat pad volume (IPFP) measured on MRI with imaging features of knee osteoarthritis. This cross-sectional study used baseline data from the Osteoarthritis Initiative. IPFPwas quantified using a deep learning algorithm for automatic volumetric IPFP segmentation. Outcomes by subregion included cartilage thickness in the lateral tibia (LT), medial tibia (MT), lateral femur (LF), medial femur (MF), and patella, along with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scores for cartilage, bone marrow edema-like lesions (BMELL), and menisci across the same subregions and the trochlea. Linear regression models included an interaction term between IPFPand subregion. When interactions were significant, subregion-specific associations were estimated. Models were adjusted for relevant confounders. A total of 4,257 participants were included in the final analysis. Significant interactions between IPFPand subregion were observed for cartilage thickness and all three WORMS scores (all p<0.001). Larger IPFPwas associated with greater cartilage thickness in the patella (&#x3b2; = 0.011 mm per cm&#xb3;; 95% CI, 0.006 to 0.016) and LT (&#x3b2; = 0.015 mm per cm&#xb3;; 95% CI, 0.010 to 0.019). For WORMS, larger IPFPwas associated with lower cartilage lesion scores in the patella (&#x3b2; = -0.036 points per cm&#xb3;; 95% CI, -0.061 to -0.010), LF (&#x3b2; = -0.058 points per cm&#xb3;; 95% CI, -0.076 to -0.039), and LT (&#x3b2; = -0.079 points per cm&#xb3;; 95% CI, -0.099 to -0.060), along with lower BMELL scores in the LT (&#x3b2; = -0.027 points per cm&#xb3;; 95% CI, -0.036 to -0.018) and lower lateral meniscus scores (&#x3b2; = -0.054 points per cm&#xb3;; 95% CI, -0.070 to -0.037). Larger IPFPwas associated with greater patellofemoral cartilage thickness and less cartilage damage on WORMS scores in the patellofemoral and lateral tibiofemoral joint. These findings highlight the subregion-specific relationships between IPFP volume and knee osteoarthritis features.